![]() These errors invariably affect downstream analysis/application and should therefore be identified early on to mitigate any unforeseen effects. Because of the vagaries of any platform's sequencing chemistry, the experimental processing, machine failure, and so on, the quality of sequencing reads is never perfect, and often declines as the read is extended. Biological Systems Science Division National Science Foundation (NSF) OSTI Identifier: 1625274 Grant/Contract Number: AC02-06CH113356 Resource Type: Accepted Manuscript Journal Name: Bioinformatics Additional Journal Information: Journal Volume: 27 Journal Issue: 6 Journal ID: ISSN 1367-4803 Publisher: International Society for Computational Biology - Oxford University Press Country of Publication: United States Language: English Subject: 59 BASIC BIOLOGICAL SCIENCES Biochemistry & Molecular Biology Biotechnology & Applied Microbiology Computer Science Mathematical & Computational Biology Mathematicsīackground: Next generation sequencing (NGS) technologies that parallelize the sequencing process and produce thousands to millions, or even hundreds of millions of sequences in a single sequencing run, have revolutionized genomic and genetic research. (ANL), Argonne, IL (United States) Sponsoring Org.: USDOE Office of Science (SC), Biological and Environmental Research (BER). Publication Date: Fri Jan 28 00:00: Research Org.: Argonne National Lab. ![]() Mathematics and Computer Science Division of Computer Science Argonne National Lab.
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